TECHNOLOGY

LaserLeap is a patented technology to deliver medicines and cosmetics through the skin. It is based on the generation of high-frequency ultrasound using a portable laser and a small device (piezophotonic materials) that efficiently converts light pulses into pressure waves. The pressure waves are painless but capable of changing the skin structure for a couple of minutes, enough time to facilitate the transport of medicines and cosmetics through the skin. The process is safe because the exposure to ultrasound in less than that used in physiotherapy and the skin recovers its protective function in few minutes. The cosmetic outcome is perfect because the skin is not punctured and always looks healthy and intact.

 

LaserLeap uses an unparalleled technology. One short laser pulse is totally absorbed by a light-to-pressure converter material, capable of producing high-frequency ultrasound waves. This ultrasound is attenuated by the various skin layers and in this process transmits its momentum to some components of the skin. Such skin components are displaced from their normal positions and channels are created to facilitate the permeation of cosmetics and drugs. The natural elasticity of skin brings its components back to their original positions and closes the channels. Typically, a few laser pulses are applied for 1 or 2 minutes to facilitate the transport of large molecules and proteins through the skin.

PUBLICATIONS

“Photoacoustic waves as a skin permeation enhancement method”

G.F.F. Sá, C. Serpa, L.G. Arnaut

in Percutaneous penetration enhancers. Physical Methods in Penetration Enhancement, N. Dragicevic-Curic, H.I. Maibach (Editors), Springer, 2015.

 

“Stratum corneum permeabilization with photoacoustic waves generated by piezophotonic materials”

G.F.F. Sá, C. Serpa, L.G. Arnaut

 J. Control. Release, 167 (2013) 290-300.

http://dx.doi.org/10.1016/j.jconrel.2013.02.005

 

 “Mechanisms of interaction between very high-frequency photoacoustic waves and the skin”

G.F.F. Sá, C. Serpa, L.G. Arnaut

Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85531Z (2012).

http://dx.doi.org/10.1117/12.2007326

 

“Intense, high-frequency pressure waves produced with low laser fluencies”

C. Serpa, G.F.F. Sá, L.G. Arnaut

Proc. SPIE Vol. 8207, 82070I (2012).

http://dx.doi.org/10.1117/12.908422

 

 “Device for the efficient delivery of compounds to or through the skin or biological barriers, using ligh-absorbing thin films”

Gonçalo F. F. Sá, Carlos A. L. Serpa Soares, Luis. G. S. Arnaut Moreira, Universidade de Coimbra.

Patent application nº 20111000030526, Priority date: 19 April 2011. PCT/PT2012/000013, EP2699304A2, WO2012144916A3, CA2832414A1, CN103492020A, US20140046246,

http://www.google.com/patents/WO2012144916A2?cl=en

 

“Analytical solution for time-resolved photoacoustic calorimetry data and applications to two typical photoreactions”

F. A. Schaberle, R. M. D. Nunes, M. Barroso, C. Serpa, L. G. Arnaut

Photochem. Photobiol. Sci., 9 (2010) 812-822.

http://dx.doi.org/10.1039/C0PP00025F

 

“Photoacoustic Measurement of Electron Injection Efficiencies and Energies from Excited Sensitizer Dyes into Nanocrystalline TiO2 Films”

C. Serpa, J. Schabauer, A. P. Piedade, Carlos J. P. Monteiro, M. M. Pereira, P. Douglas, H. D. Burrows, L. G. Arnaut

J. Am. Chem. Soc., 130 (2008), 8876–8877

http://dx.doi.org/10.1021/ja801928z

 

“Recent advances in photoacoustic calorimetry - theoretical basis and improvements in experimental design”

L. G. Arnaut, R. A. Caldwell, J. E. Elbert and L. A. Melton

Rev. Sci. Instrum., 1992, 63, 5381–5389.

http://dx.doi.org/10.1063/1.1143407

PRIZES

Tech All Stars, 12 Best Startups in Europe, 2014

 

SPIE Photonics West Biophotonics Startup Challenge, 2012

First-place winner of the entrepreneurs startup pitch presentation.

 

Prize AVCRI, 2010

Agency for the Valuation and Commercialization of Research Results of the Red Universitaria Ibero-americana de Incubación de Empresas (RedEmprendia/Santander). Ibero-American Universities competitive prize.

 

BES-Innovation Prize, 2008

The most competitive Portuguese innovation prize, Winner in the category of Health and the Grand Prize for all categories.